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Zhifei Biological's HPV Vaccine Revenue Share Continues to Decline

#智飞生物 #HPV疫苗 #收入下滑 #市场饱和 #国产替代 #生物医药 #业绩预亏
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January 20, 2026

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According to public information, Zhifei Biological (SZ300122)'s HPV vaccine revenue share shows a significant downward trend, with specific data as follows [1][2][3]:

Changes in HPV Vaccine Revenue Share
Period Proportion of HPV Vaccine-related Revenue Remarks
2023
Approximately
98.05%
Agency product revenue was RMB 51.885 billion, accounting for 98.05% of total revenue
2024
Approximately
94.61%
Agency product revenue accounted for 94.61% of total revenue; total revenue was RMB 26.07 billion
First Half of 2025
Approximately
88.84%
Agency product revenue accounted for 88.84% of total revenue; agency revenue was RMB 4.37 billion
Analysis of Decline Magnitude

The revenue share of HPV vaccines (agency business) dropped from approximately

98% in 2023 to about 89% in the first half of 2025
, a
decrease of nearly 9 percentage points
[1][2].

This decline is mainly due to:

  1. Saturated Market Demand
    : In 2024, the first-dose coverage rate of HPV vaccines among women aged 9-45 in China reached 27.43%, and the vaccination rate in core cities is approaching saturation [1]

  2. Accelerated Domestic Substitution
    : In June 2025, Wantai Biological launched a domestic 9-valent HPV vaccine priced at only RMB 499 per dose, which is less than 40% of the price of imported products [2]

  3. Significant Performance Decline
    : In 2024, revenue fell 50.74% year-on-year to RMB 26.07 billion, and agency revenue dropped 75.16% year-on-year in the first half of 2025 [2]

References

[1] Eastmoney.com - Zhifei Biological Research Report (https://pdf.dfcfw.com/pdf/H3_AP202405221634335869_1.pdf)

[2] Phoenix Net Finance - Zhifei Biological Expected to Report a Loss of RMB 10.7 Billion to 13.7 Billion in 2025 (https://finance.ifeng.com/c/8q2Jx0uCtCb)

[3] OFweek - Zhifei Biological with RMB 48 Billion in Revenue, Inventory Exceeds RMB 20 Billion (https://mp.ofweek.com/biotech/a156714070627)

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